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Literature summary for 2.7.11.13 extracted from

  • Baldanzi, G.; Alchera, E.; Imarisio, C.; Gaggianesi, M.; Dal Ponte, C.; Nitti, M.; Domenicotti, C.; van Blitterswijk, W.J.; Albano, E.; Graziani, A.; Carini, R.
    Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning (2010), Cell Death Differ., 17, 1059-1068.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
diacylglycerol the membrane recruitment and activation of PKCdelta and PKCepsilon is fully dependent on their direct interaction with diacylglycerol generated by adenosine A2a receptor-induced activation of phospholipase C-gamma, through a mechanism requiring both Src and phosphatidylinositol 3-kinase activities Rattus norvegicus
R59949 increases isofom PKCdelta and PKCepsilon activities in both membrane and cytosolic fractions Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cheletrytrine complete inhibition at 0.05 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protein A Sepharose column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
HTC cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
PKCdelta isoform Rattus norvegicus
PKCepsilon isoform Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus