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Literature summary for 2.7.11.13 extracted from

  • Kang, J.H.; Asai, D.; Yamada, S.; Toita, R.; Oishi, J.; Mori, T.; Niidome, T.; Katayama, Y.
    A short peptide is a protein kinase C (PKC) alpha-specific substrate (2008), Proteomics, 8, 2006-2011.
    View publication on PubMed
Search for more literature for 2.7.11.13

Inhibitors

Inhibitors Comment Organism Structure
additional information isozyme PKCalpha is not inhibited by H-89 and rottlerin Homo sapiens
Ro-31-7549 specific inhibitor for isozyme PKCalpha Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0166
-
 FKKQGSFAKKK isozyme PKCeta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0174
-
 FKKQGSFAKKK isozyme PKCalpha, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0205
-
 FKKQGSFAKKK isozyme PKCzeta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0229
-
 FKKQGSFAKKK isozyme PKCepsilon, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0258
-
 FKKQGSFAKKK isozyme PKCiota/lambda, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.034
-
 FKKQGSFAKKK isozyme PKCtheta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0347
-
 FKKQGSFAKKK isozyme PKCgamma, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0356
-
 FKKQGSFAKKK isozyme PKCbetaI, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0422
-
 FKKQGSFAKKK isozyme PKCdelta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens
0.0599
-
 FKKQGSFAKKK isozyme PKCbetaII, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P05129
-
-
Homo sapiens P05771
-
-
Homo sapiens P17252
-
-
Homo sapiens P24723
-
-
Homo sapiens P41743
-
-
Homo sapiens Q02156
-
-
Homo sapiens Q04759
-
-
Homo sapiens Q05513
-
-
Homo sapiens Q05655
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell shows higher levels of PKCalpha than normal breast tissue Homo sapiens
-
Hep-G2 cell shows higher levels of PKCalpha than normal liver tissue Homo sapiens
-
liver
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + FKKQGSFAKKK highly specific substrate for isozyme PKCalpha relative to other isozymes, 60% phosphorylation rate with isozyme PKCalpha, less than 20% phosphorylation rate with other PKC isozymes Homo sapiens ADP + phosphorylated FKKQGSFAKKK
-
 ?

Synonyms

Synonyms Comment Organism
PKCalpha isozyme Homo sapiens
PKCbeta1 isozyme Homo sapiens
PKCbeta2 isozyme Homo sapiens
PKCdelta isozyme Homo sapiens
PKCepsilon isozyme Homo sapiens
PKCeta isozyme Homo sapiens
PKCgamma isozyme Homo sapiens
PKCiota/lambda isozyme Homo sapiens
PKCtheta isozyme Homo sapiens
PKCzeta isozyme Homo sapiens