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Literature summary for 2.7.11.13 extracted from

  • Cerda, S.R.; Mustafi, R.; Little, H.; Cohen, G.; Khare, S.; Moore, C.; Majumder, P.; Bissonnette, M.
    Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators (2006), Oncogene, 25, 3123-3138.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
12-O-Tetradecanoylphorbol 13-acetate activates PKC isozymes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of isozyme PKC-delta in Caco-2 cells leads to increased cell proliferation and apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozyme PKC-delta inhibits colon cancer cell proliferation by selective changes in cell cycle, arresting cells in the G1 phase, and cell death regulators enhancing apoptosis using two different mechanisms, e.g. by downregulation expression of cyclin E and D1, and Bcl-2, inducing Bax expression, and altering levels of p27Kip1 and p21Waf1, PKC-delta is thus an important tumor suppressor in colonic carcinogenesis, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
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 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme PKC-delta inhibits colon cancer cell proliferation by selective changes in cell cycle, arresting cells in the G1 phase, and cell death regulators enhancing apoptosis using two different mechanisms, e.g. by downregulation expression of cyclin E and D1, and Bcl-2, inducing Bax expression, and altering levels of p27Kip1 and p21Waf1, PKC-delta is thus an important tumor suppressor in colonic carcinogenesis, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PKC
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 Homo sapiens