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Literature summary for 2.7.11.13 extracted from
- Specific protein kinase C isoforms as transducers and modulators of insulin signaling (2006), Mol. Genet. Metab., 89, 32-47.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| fatty acids | activation mechanism | Mus musculus |  |
| fatty acids | activation mechanism | Homo sapiens | |
| fatty acids | activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance | Rattus norvegicus | |
| Insulin | activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism | Mus musculus | |
| Insulin | activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism | Homo sapiens | |
| Insulin | activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance | Rattus norvegicus | |
| palmitate | activates isozyme PKCtheta, but not isozymes PKCalpha and PKCepsilon | Rattus norvegicus | |
| phosphatidylserine | activation mechanism | Mus musculus | |
| phosphatidylserine | activation mechanism | Homo sapiens | |
| phosphatidylserine | activation mechanism | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview | Mus musculus |
| co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview | Homo sapiens |
| co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CG53353 | inhibitor of isozyme PKCbetaII | Homo sapiens | |
| CG53353 | inhibitor of isozyme PKCbetaII | Mus musculus | |
| CG53353 | inhibitor of isozyme PKCbetaII | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation mechanism | Mus musculus | |
| Ca2+ | activation mechanism | Homo sapiens | |
| Ca2+ | activation mechanism | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview | ? | - |
? | |
| additional information | Homo sapiens | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview | ? | - |
? | |
| additional information | Rattus norvegicus | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
conventional, novel, and atypical isozyme types, overview | - |
| Mus musculus | - |
conventional, novel, and atypical isozyme types, overview | - |
| Rattus norvegicus | - |
conventional, novel, and atypical isozyme types, overview | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Mus musculus | - |
| adipocyte | - |
Homo sapiens | - |
| adipocyte | - |
Rattus norvegicus | - |
| adipose tissue | - |
Mus musculus | - |
| adipose tissue | - |
Homo sapiens | - |
| adipose tissue | - |
Rattus norvegicus | - |
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| cell culture | primary | Mus musculus | - |
| cell culture | primary | Homo sapiens | - |
| cell culture | primary | Rattus norvegicus | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| fibroblast | - |
Rattus norvegicus | - |
| H4IIE cell | - |
Rattus norvegicus | - |
| hepatoma cell | constitutively active isozyme PKCdelta | Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| myotube | isozyme PKCbetaII | Mus musculus | - |
| myotube | isozyme PKCbetaII | Homo sapiens | - |
| myotube | isozyme PKCbetaII | Rattus norvegicus | - |
| NIH-3T3 cell | - |
Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
| skeletal muscle | - |
Homo sapiens | - |
| skeletal muscle | isozyme PKCtheta is decreased in obese patients' skeletal muscle | Rattus norvegicus | - |
| white muscle | increased expresison of isozyme PKCtheta in insulin-resistant rats | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Akt | phosphorylation on Ser473 by isozyme PKCbetaII | Mus musculus | ADP + phosphorylated Akt | - |
? | |
| ATP + Akt | phosphorylation on Ser473 by isozyme PKCbetaII | Homo sapiens | ADP + phosphorylated Akt | - |
? | |
| ATP + Akt | phosphorylation on Ser473 by isozyme PKCbetaII | Rattus norvegicus | ADP + phosphorylated Akt | - |
? | |
| ATP + insulin receptor | isozyme PKCalpha | Mus musculus | ADP + phosphorylated insulin receptor | - |
? | |
| ATP + insulin receptor | isozyme PKCalpha | Homo sapiens | ADP + phosphorylated insulin receptor | - |
? | |
| ATP + insulin receptor | isozyme PKCalpha | Rattus norvegicus | ADP + phosphorylated insulin receptor | - |
? | |
| ATP + IRS | isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 | Mus musculus | ADP + phosphorylated IRS | - |
? | |
| ATP + IRS | isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 | Homo sapiens | ADP + phosphorylated IRS | - |
? | |
| ATP + IRS | isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 | Rattus norvegicus | ADP + phosphorylated IRS | - |
? | |
| additional information | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview | Mus musculus | ? | - |
? | |
| additional information | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview | Homo sapiens | ? | - |
? | |
| additional information | regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle | Rattus norvegicus | ? | - |
? | |
| additional information | PKCbetaII specifically binds to beta-actin | Mus musculus | ? | - |
? | |
| additional information | PKCbetaII specifically binds to beta-actin | Homo sapiens | ? | - |
? | |
| additional information | PKCbetaII specifically binds to beta-actin | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Mus musculus |
| PKC | - |
Homo sapiens |
| PKC | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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