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Literature summary for 2.7.11.13 extracted from

  • Budas, G.R.; Koyanagi, T.; Churchill, E.N.; Mochly-Rosen, D.
    Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic (2007), Biochem. Soc. Trans., 35, 1021-1026.
    View publication on PubMed
Search for more literature for 2.7.11.13

Inhibitors

Inhibitors Comment Organism Structure
AVGPRPQT
-
 Homo sapiens
CRLVLASC targets isozyme PKCgamma, blocks formalin-induced pain response Homo sapiens
EAVSLKPT targets isozyme PKCepsilon, reverses psi epsilonRACK-mediated protection, and decreases formalin-induced pain response Homo sapiens
FLLDPY
-
 Homo sapiens
FNGLLKIKI protects from cardiac ischaemic injury Homo sapiens
HDAPIGYD protects from cardiac ischaemic injury, from graft coronary artery disease, and activates potassium current, inhibits sodium current Homo sapiens
KGDYEKILVALCGGN targets isozyme PKCbeta Homo sapiens
KGDYEKILVALCGGN blocks Xenopus oocyte maturation Xenopus laevis
KLFIMNL targets isozyme PKCbetaI, inhibits cardiomyocyte hypertrophy Homo sapiens
KQKTKTIK T targets isozyme PKCbeta Homo sapiens
KQKTKTIK T blocks Xenopus oocyte maturation Xenopus laevis
LEPEGK
-
 Homo sapiens
MDPNGLSDPYVKL targets isozyme PKCbeta, blocks Ca2+ current Homo sapiens
additional information peptides derived from the PKC-cognate proteins are useful competitive inhibitors of PKC signalling, inhibitory peptide inhibit enzyme activity and/or enzyme translocation, physiological effects, overview Homo sapiens
MRAAEDPM increased injury from cardiac ischaemia Homo sapiens
NGRKI
-
 Homo sapiens
PAWHD
-
 Homo sapiens
PYIALNVD
-
 Homo sapiens
QEVIRNN targets isozyme PKCbetaII, inhibits cardiomyocyte hypertrophy and activates potassium channels Homo sapiens
RACK1 peptide I homologue
-
 Homo sapiens
SFNSYELGSL targets isozyme PKCdelta, protects from cardiac ischaemic injury, from cerebral injury, from graft coronary artery disease, and increases fibroblast proliferation Homo sapiens
SIKIWD targets isozyme PKCbeta Homo sapiens
SIYRRGARRWRKLYRAN targets isozyme PKCzeta, which leads to inhibition of fibroblast proliferation Homo sapiens
SLNPEWNE targets isozyme PKCbeta Homo sapiens
SRIGQ
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PKC
-
 Homo sapiens
PKC
-
 Xenopus laevis