Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,2-diolein | activates, required | Giardia intestinalis | |
diacylglycerol | activates | Giardia intestinalis | |
phosphatidylserine | activates, required | Giardia intestinalis | |
Phospholipids | activate | Giardia intestinalis |
Cloned (Comment) | Organism |
---|---|
gene pkcb, isozyme PKCbeta, DNA and amino acid sequence determination and analysis, expression of the catalytic domain from PKCbeta | Giardia intestinalis |
General Stability | Organism |
---|---|
native PKCbeta is very sensitive to protease degradation | Giardia intestinalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BIM-I | inhibits encystment in vivo | Giardia intestinalis | |
calphostin C | interacts with the regulatory domain of PKC, inhibits encystment in vivo | Giardia intestinalis | |
chelerythrine chloride | interacts with the catalytic domain of PKC, inhibits encystment in vivo | Giardia intestinalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | PKC is commonly associated with a rapid redistribution of the kinase from the cytosol to membranes | Giardia intestinalis | 5829 | - |
intracellular | intracellular localization pattern during cyst formation | Giardia intestinalis | 5622 | - |
membrane | PKC is commonly associated with a rapid redistribution of the kinase from the cytosol to membranes | Giardia intestinalis | 16020 | - |
additional information | subcellular localization study, during encystment PKCbeta redistributs to plasma membrane from cytosol | Giardia intestinalis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates, required | Giardia intestinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1-IIIS | Giardia intestinalis | isozyme PKCbeta | ADP + phosphorylated histone H1-IIIS | - |
? | |
additional information | Giardia intestinalis | isozyme PKCbeta is involved in encystment | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Giardia intestinalis | Q1H8W8 | isozyme PKCbeta; WB strain, ATCC 30957, isozymes beta, delta, epsilon, theta and zeta | - |
Purification (Comment) | Organism |
---|---|
native isozyme partially by anion exchange chromatography and gel filtration | Giardia intestinalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
encysting cell | - |
Giardia intestinalis | - |
trophozoite | - |
Giardia intestinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1-IIIS | isozyme PKCbeta | Giardia intestinalis | ADP + phosphorylated histone H1-IIIS | - |
? | |
additional information | isozyme PKCbeta is involved in encystment | Giardia intestinalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the family of serine/threonine kinases | Giardia intestinalis |
PKC | - |
Giardia intestinalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Giardia intestinalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Giardia intestinalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Giardia intestinalis |