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Literature summary for 2.7.11.13 extracted from

  • Bazan-Tejeda, M.L.; Argueello-Garcia, R.; Bermudez-Cruz, R.M.; Robles-Flores, M.; Ortega-Pierres, G.
    Protein kinase C isoforms from Giardia duodenalis: identification and functional characterization of a beta-like molecule during encystment (2007), Arch. Microbiol., 187, 55-66.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1,2-diolein activates, required Giardia intestinalis
diacylglycerol activates Giardia intestinalis
phosphatidylserine activates, required Giardia intestinalis
Phospholipids activate Giardia intestinalis

Cloned(Commentary)

Cloned (Comment) Organism
gene pkcb, isozyme PKCbeta, DNA and amino acid sequence determination and analysis, expression of the catalytic domain from PKCbeta Giardia intestinalis

General Stability

General Stability Organism
native PKCbeta is very sensitive to protease degradation Giardia intestinalis

Inhibitors

Inhibitors Comment Organism Structure
BIM-I inhibits encystment in vivo Giardia intestinalis
calphostin C interacts with the regulatory domain of PKC, inhibits encystment in vivo Giardia intestinalis
chelerythrine chloride interacts with the catalytic domain of PKC, inhibits encystment in vivo Giardia intestinalis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PKC is commonly associated with a rapid redistribution of the kinase from the cytosol to membranes Giardia intestinalis 5829
-
intracellular intracellular localization pattern during cyst formation Giardia intestinalis 5622
-
membrane PKC is commonly associated with a rapid redistribution of the kinase from the cytosol to membranes Giardia intestinalis 16020
-
additional information subcellular localization study, during encystment PKCbeta redistributs to plasma membrane from cytosol Giardia intestinalis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, required Giardia intestinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + histone H1-IIIS Giardia intestinalis isozyme PKCbeta ADP + phosphorylated histone H1-IIIS
-
?
additional information Giardia intestinalis isozyme PKCbeta is involved in encystment ?
-
?

Organism

Organism UniProt Comment Textmining
Giardia intestinalis Q1H8W8 isozyme PKCbeta; WB strain, ATCC 30957, isozymes beta, delta, epsilon, theta and zeta
-

Purification (Commentary)

Purification (Comment) Organism
native isozyme partially by anion exchange chromatography and gel filtration Giardia intestinalis

Source Tissue

Source Tissue Comment Organism Textmining
encysting cell
-
Giardia intestinalis
-
trophozoite
-
Giardia intestinalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1-IIIS isozyme PKCbeta Giardia intestinalis ADP + phosphorylated histone H1-IIIS
-
?
additional information isozyme PKCbeta is involved in encystment Giardia intestinalis ?
-
?

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the family of serine/threonine kinases Giardia intestinalis
PKC
-
Giardia intestinalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Giardia intestinalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Giardia intestinalis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Giardia intestinalis