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Literature summary for 2.7.11.13 extracted from

  • Nozawa, Y.; Nishihara, K.; Akizawa, Y.; Orimoto, N.; Nakano, M.; Uji, T.; Ajioka, H.; Kanda, A.; Matsuura, N.; Kiniwa, M.
    Protein kinase C activation by Helicobacter pylori in human gastric epithelial cells limits interleukin-8 production through suppression of extracellular signal-regulated kinase (2004), J. Pharmacol. Sci., 94, 233-239.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
additional information Helicobacter pylori activates the enzyme in gastric epithelial cells Homo sapiens
phorbol 12-myristate 13-acetate
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calphostin C PKC-specific inhibitor Homo sapiens
GF109203X PKC-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Helicobacter pylori activates the enzyme in gastric epithelial cells limiting interleukin-8 production, induced by the pathogen, through suppression of extracellular signal-regulated kinase ERK activation, mechanism overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
gastric epithelial cell
-
 Homo sapiens
-
MKN-45 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Helicobacter pylori activates the enzyme in gastric epithelial cells limiting interleukin-8 production, induced by the pathogen, through suppression of extracellular signal-regulated kinase ERK activation, mechanism overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at, in vivo Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens