Literature summary for 2.7.11.13 extracted from

Becker, K.P.; Hannun, Y.A.
Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D (2004), J. Biol. Chem., 279, 28251-28256.

Search for more literature for 2.7.11.13

Activating Compound

Activating Compound	Comment	Organism	Structure
phorbol 12-myristate 13-acetate	i.e. PMA	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
isozymes PKCbetaII and PKCbetaI are products of alternative splicing of gene PKCbeta, expression of GFP- or HA-tagged isozymes PKCbetaII, wild-type and mutant, and PKCbetaI in HEK-293 or HeLa cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K371R	site-directed mutagenesis, inactive isozyme PKCbetaII mutant	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	non-activated PKCbetaII and PKCbetaI	Homo sapiens	5737	-
endosome	activated PKCbetaII and PKCbetaI are translocated from cytosol, juxtanuclear location, isozyme-specific translocation of PKCbetaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes, involvement of phospholipase D	Homo sapiens	5768	-
additional information	subcellular distribution of isozymes PKCbetaII and PKCbetaI	Homo sapiens	-	-
plasma membrane	activated PKCbetaII and PKCbetaI are translocated from cytosol	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes PKCbetaII and PKCbetaI	-

Synonyms

Synonyms	Comment	Organism
PKC	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)