Any feedback?
Literature summary for 2.7.11.13 extracted from
- Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets (2003), J. Biol. Chem., 278, 24533-24541.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition of PKCdelta by bisindolylmaleimide I | Homo sapiens | |
| rottlerin | inhibits PKCdelta, but does not block its translocation | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| additional information | PKCdelta is translocated from cytosol to plasma membrane in platelets activated by the snake venom alboaggregin-A | Homo sapiens | - |
- |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
| Mn2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
several isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | isozyme PKCdelta | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Fyn | Fyn is a tyrosine protein kinase of the Src family, phosphorylation at a serine residue | Homo sapiens | ADP + phosphorylated Fyn | - |
? | |
| additional information | interaction between PKCdelta and Fyn leads to phosphorylation on tyrosine and on serine, respectively, with Fyn kinase being activated by the snake venom alboaggregin-A | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKCdelta | - |
Homo sapiens |
| protein kinase C delta | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
