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Literature summary for 2.7.11.13 extracted from

  • Tan, S.L.; Parker, P.J.
    Emerging and diverse roles of protein kinase C in immune cell signalling (2003), Biochem. J., 376, 545-552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
additional information PKC isozymes interacting proteins, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of isozyme-knockout mice, immunological phenotypes of isozyme alpha, beta, delta, epsilon, theta, and zeta knockout mice, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information PKC isozymes interacting proteins, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
membrane
-
 Mus musculus 16020
-
microtubule isozymes PKC-beta and PKC-gamma are recruited to microtubules by LFA-1 signalling, i.e. lymphocyte-function-associated antigen-1 signalling Mus musculus 5874
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 several isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-
additional information PKC isozymes are expressed in a wide range of tissues, some isozymes are tissue-specific Mus musculus
-
RAW-264.7 cell virus-induced macrophage cell line Mus musculus
-
skeletal muscle isozyme theta Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells Mus musculus ?
-
 ?
additional information substrate specificity of PKC isozymes, PKC isozymes interacting proteins, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More PKC domain structure, overview Mus musculus

Synonyms

Synonyms Comment Organism
PKC
-
 Mus musculus