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Literature summary for 2.7.11.13 extracted from
- Pseudosubstrate-based peptide inhibitors (1991), Methods Enzymol., 201, 287-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FTRKRQRAMRRVHQ | autoregulatory pseudosubstrate sequence, residues 24-40, lung enzyme | Homo sapiens |  |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Drosophila melanogaster | |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential, sequences of the different enzyme forms, required sequence properties, overview | eukaryota | |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Homo sapiens | |
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Saccharomyces cerevisiae | |
| NKMKSRLRKGALKKNV | autoregulatory pseudosubstrate sequence, residues 24-40 | Drosophila melanogaster | |
| QLMGGLHRHGAIINRKE | autoregulatory pseudosubstrate sequence, residues 391-407 | Saccharomyces cerevisiae | |
| Tween 80 | inhibits the enzyme at high concentration | Drosophila melanogaster | |
| Tween 80 | inhibits the enzyme at high concentration | eukaryota | |
| Tween 80 | inhibits the enzyme at high concentration | Homo sapiens | |
| Tween 80 | inhibits the enzyme at high concentration | Saccharomyces cerevisiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Drosophila melanogaster | |
| Mg2+ | - |
eukaryota | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Drosophila melanogaster | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | Saccharomyces cerevisiae | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| eukaryota | - |
enzyme forms alpha, betaI ans betaII, gamma, epsilon, delta, zeta | - |
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Drosophila melanogaster | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Saccharomyces cerevisiae | ADP + a phosphoprotein | - |
? | |
| additional information | substrate specificity | Drosophila melanogaster | ? | - |
? | |
| additional information | substrate specificity | eukaryota | ? | - |
? | |
| additional information | substrate specificity | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Drosophila melanogaster |
| PKC | - |
eukaryota |
| PKC | - |
Homo sapiens |
| PKC | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
| ATP | - |
eukaryota | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Drosophila melanogaster | |
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota | |
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Homo sapiens | |
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Saccharomyces cerevisiae |
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