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Literature summary for 2.7.11.12 extracted from

  • Peng, Q.; Wang, Y.; Li, M.; Yuan, D.; Xu, M.; Li, C.; Gong, Z.; Jiao, R.; Liu, L.
    cGMP-Dependent protein kinase encoded by foraging regulates motor axon guidance in Drosophila by suppressing Lola function (2016), J. Neurosci., 36, 4635-4646 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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Drosophila melanogaster
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ventral nerve cord
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Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme PKG physically interacts with transcription factor LolaT both in vitro and in vivo Drosophila melanogaster ?
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Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
FOR
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Drosophila melanogaster
PKG
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Drosophila melanogaster

General Information

General Information Comment Organism
malfunction Drosophila embryos display targeting defects during axon development in the absence of the enzyme gene Drosophila melanogaster
physiological function the enzyme is required for CNS axon guidance. Enzyme overexpression leads to the cytoplasmic retention of transcription factor LolaT in S2 cells, suggesting a role for the enzyme in mediating the nucleocytoplasmic trafficking of Lola. The enzyme plays a role in regulating the establishment of neuronal connectivity by sequestering transcription factor Lola in the cytoplasm Drosophila melanogaster