Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Drosophila melanogaster | - |
ventral nerve cord | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme PKG physically interacts with transcription factor LolaT both in vitro and in vivo | Drosophila melanogaster | ? | - |
- |
Subunits | Comment | Organism |
---|---|---|
? | x * 110000, SDS-PAGE | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
FOR | - |
Drosophila melanogaster |
PKG | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | Drosophila embryos display targeting defects during axon development in the absence of the enzyme gene | Drosophila melanogaster |
physiological function | the enzyme is required for CNS axon guidance. Enzyme overexpression leads to the cytoplasmic retention of transcription factor LolaT in S2 cells, suggesting a role for the enzyme in mediating the nucleocytoplasmic trafficking of Lola. The enzyme plays a role in regulating the establishment of neuronal connectivity by sequestering transcription factor Lola in the cytoplasm | Drosophila melanogaster |