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Literature summary for 2.7.11.12 extracted from

  • Large, J.M.; Birchall, K.; Bouloc, N.S.; Merritt, A.T.; Smiljanic-Hurley, E.; Tsagris, D.J.; Wheldon, M.C.; Ansell, K.H.; Coombs, P.J.; Kettleborough, C.A.; Whalley, D.; Stewart, L.B.; Bowyer, P.W.; Baker, D.A.; Osborne, S.A.
    Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase approaches to combining improvements in cell potency, selectivity and structural novelty (2019), Bioorg. Med. Chem. Lett., 29, 126610 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
4-[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[2-cyclopropyl-7-[(dimethylamino)methyl]imidazo[1,2-a]pyridin-3-yl]-N-(propan-2-yl)pyrimidin-2-amine
-
 Plasmodium falciparum
4-[2-cyclopropyl-7-[(dimethylamino)methyl]imidazo[1,2-a]pyridin-3-yl]-N-(pyridin-2-yl)pyrimidin-2-amine
-
 Plasmodium falciparum
4-[2-cyclopropyl-7-[(dimethylamino)methyl]imidazo[1,2-a]pyridin-3-yl]-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[2-cyclopropyl-7-[(dimethylamino)methyl]imidazo[1,2-a]pyridin-3-yl]-N-[4-(piperazin-1-yl)phenyl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[2-cyclopropyl-7-[(dimethylamino)methyl]imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[6-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[7-[2-(dimethylamino)ethoxy]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[7-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
4-[8-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
-
 Plasmodium falciparum
N2-[2-(4-fluorophenyl)-3-[2-(methylamino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-7-yl]-N1,N1-dimethylethane-1,2-diamine
-
 Plasmodium falciparum
N2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]-N1,N1-dimethylethane-1,2-diamine
-
 Plasmodium falciparum
N3-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-6-yl]-N1,N1-dimethylpropane-1,3-diamine
-
 Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Synonyms

Synonyms Comment Organism
PKG
-
 Plasmodium falciparum