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Literature summary for 2.7.11.12 extracted from

  • Lan, T.; Pang, J.; Wang, Z.; Wang, Y.; Qian, H.; Chen, Y.; Wu, Y.
    Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation (2019), Biochem. Biophys. Res. Commun., 518, 14-18 .
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-(4-chlorophenylthio) guanosine-3',5'-cyclic monophosphate
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + epidermal growth factor receptor Homo sapiens the enzyme phosphorylates epidermal growth factor receptor at threonine 669 and thereby inhibits its activation ADP + phosphorylated epidermal growth factor receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
gastric cancer cell
-
 Homo sapiens
-
HGC-27 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + epidermal growth factor receptor the enzyme phosphorylates epidermal growth factor receptor at threonine 669 and thereby inhibits its activation Homo sapiens ADP + phosphorylated epidermal growth factor receptor
-
 ?

Synonyms

Synonyms Comment Organism
PKG II
-
 Homo sapiens
Type II cGMP-dependent protein kinase
-
 Homo sapiens