Literature summary for 2.7.11.12 extracted from

Cao, Z.H.; Tao, Y.; Sang, J.R.; Gu, Y.J.; Bian, X.J.; Chen, Y.C.
Type II, but not type I, cGMP-dependent protein kinase reverses bFGF-induced proliferation and migration of U251 human glioma cells (2013), Mol. Med. Rep., 7, 1229-1234.

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Activating Compound

Activating Compound	Comment	Organism	Structure
8-(4-chlorophenylthio)-3',5'-cyclic GMP	-	Homo sapiens
8-bromo-cGMP	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U-251 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PKG I	-	Homo sapiens
type I cGMP-dependent protein kinase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform PKG II activity attenuates basic fibroblast growth factorinduced proliferation and migration by inhibiting the MAPK/ERK signaling pathway in glioma cells, whereas isoform PKG I does not	Homo sapiens

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Release 2023.1 (January 2023)