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Literature summary for 2.7.11.12 extracted from

  • Castro, L.R.; Schittl, J.; Fischmeister, R.
    Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes (2010), Circ. Res., 107, 1232-1240.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
DT-2 peptide
-
 Rattus norvegicus
KT5823 effect of KT5823 is abolished in the presence of the nonselective cyclic nucleotide PDE inhibitor 3-isobutyl-1-methylxantine or the selective cGMP-PDE5 inhibitor sildenafil Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocyte adult rat ventricular, and caridac Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PKG
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction PKG inhibition also potentiates the effect of SNAP on global cGMP levels and fully blocks the increase in cGMP-PDE5 activity Rattus norvegicus
metabolism cGMP-dependent protein kinase exerts a feedback control on cGMP concentration contributing to its intracellular compartmentation Rattus norvegicus
physiological function cGMP-dependent protein kinase exerts a feedback control on cGMP concentration contributing to its intracellular compartmentation, negative feedback of PKG on sGC-cGMP signaling attributable to PDE5 activation, kinetics and overview. PKG inhibition decreases and PKG activation increases cGMP-gated current. PKG activation in adult cardiomyocytes limits the accumulation of cGMP induced by NO donors via PDE5 stimulation but increases that induced by natriuretic peptides Rattus norvegicus