Cloned (Comment) | Organism |
---|---|
SmcGK1, DNA and amino acid sequence determination and analysis, phylogenetic analysis and sequence comparisons, SmcGK1 is gender-independently transcribed in adult schistosomes, expression of the gene is controlled at the post-transcriptional level | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Rp-8-pCPT-cGMPS | a cGMP analogue | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | E7BBH9 | Liberian isolate | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gonad | of male and female worms, SmcGK1 shows a gonad-preferential expression profile in both genders | Schistosoma mansoni | - |
additional information | in situ hybridizations and immunoaffinity histochemic detection, overview | Schistosoma mansoni | - |
vitellarium | - |
Schistosoma mansoni | - |
Synonyms | Comment | Organism |
---|---|---|
cGKI | - |
Schistosoma mansoni |
cyclic guanosine-3', 5'-monophosphate-dependent protein kinase | - |
Schistosoma mansoni |
General Information | Comment | Organism |
---|---|---|
evolution | cGMP-dependent protein kinases belong to the group of serine/threonine kinases. The complete amino acid sequence of SmcGK1 indicates a greater similarity to type II cGKsof other organisms, but the sequence of SmcGK1 lacks a myristoylation motive typically found in mammalian membrane-bound cGKII, the homology to mammalian cGKII is mainly due to a high similarity of the kinase domains. SmcGK1 seems to occupy an intermediate position with respect to cGK classifications | Schistosoma mansoni |
malfunction | enzyme inhibition leads to a multifaceted phenotype including slow motion, oocyte congestion, and reduced egg production | Schistosoma mansoni |
physiological function | possible role of SmcGK1 during sexual development of schistosomes | Schistosoma mansoni |