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Literature summary for 2.7.11.12 extracted from
- Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry (2009), J. Biol. Chem., 284, 16354-16368.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cGMP | - |
Bos taurus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| bovine PKG type Ialpha is expressed in SF9 insect cells | Bos taurus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| PKG DELTA77 | N-terminal deletion mutant, which lacks the dimerization domain | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LRKKKKKH | - |
Bos taurus | |
| TQAKRKKALAMA-NH2 | - |
Bos taurus | |
| TTYDFIASGRTGRRNAIHD-NH2 | - |
Bos taurus | |
| YGRKKRRQRRRPP | - |
Bos taurus | |
| YGRKKRRQRRRPPLRKKKKKH | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 76000 | - |
monomer | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Bos taurus | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | - |
Bos taurus | - |
| lung | - |
Bos taurus | - |
| smooth muscle | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Bos taurus | ADP + a phosphoprotein | - |
? | |
| additional information | peptide substrates with a primary amino acid sequence motif RRX(S/T)X are in general recognized by PKG | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 76000 | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-dependent protein kinase | - |
Bos taurus |
| PKG | - |
Bos taurus |
| PKG type Ialpha | - |
Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000125 | - |
YGRKKRRQRRRPPLRKKKKKH | - |
Bos taurus | |
| 0.00082 | - |
LRKKKKKH | - |
Bos taurus | |
| 0.0011 | - |
YGRKKRRQRRRPP | - |
Bos taurus | |
| 0.0075 | - |
TQAKRKKALAMA-NH2 | - |
Bos taurus | |
| 0.15 | - |
TTYDFIASGRTGRRNAIHD-NH2 | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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