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Literature summary for 2.7.11.12 extracted from

  • Broderick, K.E.; Zhang, T.; Rangaswami, H.; Zeng, Y.; Zhao, X.; Boss, G.R.; Pilz, R.B.
    Guanosine 3,5-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts (2007), Mol. Endocrinol., 21, 1148-1162.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP
-
 Homo sapiens
8-bromo-cGMP
-
 Rattus norvegicus
cGMP
-
 Homo sapiens
cGMP
-
 Rattus norvegicus
additional information mechanical stress also induces the enzyme, e.g. in lung epithelial cells, umbilical vein endothelial cells, and osteoblasts Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm PKG1, primarily in cGMP untreated cells Homo sapiens 5737
-
cytoplasm PKG1, primarily in cGMP untreated cells Rattus norvegicus 5737
-
nucleus PKG1, primarily in cGMP or 8-bromo-cGMp treated cells Homo sapiens 5634
-
nucleus PKG1, primarily in cGMP or 8-bromo-cGMp treated cells Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview ?
-
 ?
additional information Rattus norvegicus transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
lung epithelium Homo sapiens
-
osteoblast primary Homo sapiens
-
osteosarcoma cell
-
 Rattus norvegicus
-
umbilical vein endothelium
-
 Homo sapiens
-
UMR-106 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview Homo sapiens ?
-
 ?
additional information transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
guanosine 3,5-cyclic monophosphate-dependent protein kinase
-
 Homo sapiens
guanosine 3,5-cyclic monophosphate-dependent protein kinase
-
 Rattus norvegicus
PKG
-
 Homo sapiens
PKG
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus