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Literature summary for 2.7.11.12 extracted from

  • Giordano, D.; Magaletti, D.M.; Clark, E.A.
    Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19 (2006), Blood, 107, 1537-1545.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Homo sapiens
lipopolysaccharides induces enzyme expression and activates the enzyme Homo sapiens
NO
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is regulated via negative feedback Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + vasodilator stimulated phosphoprotein Homo sapiens phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
additional information Homo sapiens NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell derived from CD14+ monocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + vasodilator stimulated phosphoprotein phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 Homo sapiens ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
ATP + vasodilator stimulated phosphoprotein phosphorylation at Ser239 Homo sapiens ADP + phosphorylated vasodilator stimulated phosphoprotein
-
 ?
additional information NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CGK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens