Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-Br-cGMP | - |
Mus musculus | |
cGMP | - |
Mus musculus | |
additional information | the enzyme mediates NO antiatherogenic and proatherogenic effects | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of cGKI knockout mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type and artherosclerotic mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle cell | vascular, aortic | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGKI | - |
Mus musculus |