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Literature summary for 2.7.11.12 extracted from

  • Wolfsgruber, W.; Feil, S.; Brummer, S.; Kuppinger, O.; Hofmann, F.; Feil, R.
    A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells (2003), Proc. Natl. Acad. Sci. USA, 100, 13519-13524.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
8-Br-cGMP
-
Mus musculus
cGMP
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Mus musculus
additional information the enzyme mediates NO antiatherogenic and proatherogenic effects Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of cGKI knockout mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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wild-type and artherosclerotic mice
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Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle cell vascular, aortic Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
cGKI
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Mus musculus