Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.12 extracted from

  • Grassi, C.; D'Ascenzo, M.; Azzena, G.B.
    Modulation of CaV1 and CaV2.2 channels induced by nitric oxide via cGMP-dependent protein kinase (2004), Neurochem. Int., 45, 885-893.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
8-Br-cGMP
-
Homo sapiens
cGMP dependent on Homo sapiens
additional information NO, from NO donor sodium nitroprusside, induces cGMP production and thus increases enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KT5823 specific PKG inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens NO induces enzyme activity responsible for modulation/inhibition of voltage-gated CaV1 and CaV2.2, i.e. L- and N-type, Ca2+ channels in neuroblastoma cells, in cardiovascular and smooth muscle cells Ca2+ channel activity is inhibited by direct nitrosylation of the channel proteins by NO, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IMR-32 cell neuroblastoma cell line Homo sapiens
-
neuroblastoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NO induces enzyme activity responsible for modulation/inhibition of voltage-gated CaV1 and CaV2.2, i.e. L- and N-type, Ca2+ channels in neuroblastoma cells, in cardiovascular and smooth muscle cells Ca2+ channel activity is inhibited by direct nitrosylation of the channel proteins by NO, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PKG
-
Homo sapiens