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Literature summary for 2.7.11.12 extracted from

  • Zhao, X.; Zhuang, S.; Chen, Y.; Boss, G.R.; Pilz, R.B.
    Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 (2005), J. Biol. Chem., 280, 32683-32692.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
cGMP activates both PKGI and PKGII Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of PKGI and PKGII in UMR106 cells, PKGI expression enhances the glycosynthase kinase-3 phosphorylation to a greater extent than PKGII Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycogen synthase kinase-3 Rattus norvegicus phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis ADP + phosphorylated glycogen synthase kinase 3
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 ?
additional information Rattus norvegicus cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
 Rattus norvegicus
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UMR-106 cell primary psteoblast cells Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen synthase kinase-3 phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus ADP + phosphorylated glycogen synthase kinase 3
-
 ?
ATP + glycogen synthase kinase3 phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3, substrate phosphorylation site mapping Rattus norvegicus ADP + phosphorylated glycogen synthase kinase 3
-
 ?
additional information cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Rattus norvegicus
PKGI
-
 Rattus norvegicus
PKGII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus