Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-APT-cGMP | cGKIalpha-selective activator | Rattus norvegicus | |
angiotensin | causes an increase in expression of isozyme cGKIbeta, and a decrease in expression of isozyme cGKIalpha | Rattus norvegicus | |
cGMP | - |
Rattus norvegicus | |
additional information | NO activates the enzyme through elevation of cGMP concentration, reduced in hypertensive rats due to a shift in relation of cGKIalpha to cGKIbeta | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin | causes a decrease in expression of isozyme cGKIalpha, and an increase in expression of isozyme cGKIbeta | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
normotensive and angiotensin-hypertensive rats, two isoforms cGKIalpha and cGKIbeta of enzyme form cGKI | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Maxi-K channel | - |
Rattus norvegicus | ADP + phosphorylated Maxi-K channel | - |
? | |
additional information | alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGKI | - |
Rattus norvegicus |
cGMP-dependent protein kinase I | - |
Rattus norvegicus |