Literature summary for 2.7.11.12 extracted from

Foster, J.L.; Higgins, G.C.; Jackson, F.R.
Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase (1996), J. Biol. Chem., 271, 23322-23328.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 cells	Drosophila melanogaster

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	maximal activation at 40-50 mM	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q03042	-	-

Synonyms

Synonyms	Comment	Organism
cGMP-dependent protein kinase, isozyme 1	-	Drosophila melanogaster
DG1 protein kinase	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
8-bromo-cAMP	50% activation at 0.00062 mM	Drosophila melanogaster
8-bromo-cGMP	50% activation at 0.00004 mM	Drosophila melanogaster
cAMP	50% activation at 0.0117 mM, activation is not cooperative	Drosophila melanogaster
cGMP	cGMP, 0.010 mM, stimulated histone H2B phosphorylation by the DG1 protein kinase 20-fold	Drosophila melanogaster
cGMP	50% activation at 0.00019 mM, cooperative activation	Drosophila melanogaster
cIMP	50% activation at 0.0053 mM	Drosophila melanogaster

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Release 2023.1 (January 2023)