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Literature summary for 2.7.11.11 extracted from

  • Gerlits, O.; Waltman, M.J.; Taylor, S.; Langan, P.; Kovalevsky, A.
    Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: an X-ray crystallographic study of complexes with various metals and peptide substrate SP20 (2013), Biochemistry, 52, 3721-3727.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with Mg2+ and beta,gamma-methyleneadenosine 5'-triphosphate, sitting drop vapor diffusion method, using 100 mM MES (pH 6.5), 5 mM dithiothreitol, and 15-20% (w/v) PEG 4000 at 4-14°C Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta,gamma-methyleneadenosine 5'-triphosphate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + SP20 protein Homo sapiens i.e. TTYADFIASGRTGRRASIHD ADP + phosphorylated SP20 protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P61925
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + SP20 protein i.e. TTYADFIASGRTGRRASIHD Homo sapiens ADP + phosphorylated SP20 protein
-
 ?

Synonyms

Synonyms Comment Organism
PKAc catalytic subunit Homo sapiens