Cloned (Comment) | Organism |
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DNA and amino acid sequence determination and analysis, PK-A R-subunit exons and introns, modified version of that published in WormBase, overview.Gene models R07E4.6a, R07E4.6b, and R07E4.6q, encoding isoforms A, B, and Q, RT-PCR expression analysis | Caenorhabditis elegans |
Organism | UniProt | Comment | Textmining |
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Caenorhabditis elegans | - |
single genes encode the catalytic (C) subunit (kin-1), the regulatory (R) subunit (kin-2) and an A-kinase anchor protein (AKAP) | - |
Subunits | Comment | Organism |
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dimer | in Caenorhabditis elegans, in addition to tetrameric (R2C2) PK-A holoenzymes, there is also a sub-population of dimeric (RC) PK-A enzymes that are not tethered by AKAPs | Caenorhabditis elegans |
More | the enzyme contains the catalytic C subunit, the regulatory R subunit and an A-kinase anchor protein encoded by single genes kin-1, kin-2, and AKAP, respectively. R-subunit isoforms containing exon B- or exon Q-encoded polypeptide sequences lack the dimerisation/docking domains conventionally seen in R-subunits, and are unlikely to participate in the formation of tetrameric PK-A holoenzymes and are, additionally, unlikely to interact with AKAP(s) | Caenorhabditis elegans |
tetramer | in Caenorhabditis elegans, in addition to tetrameric (R2C2) PK-A holoenzymes, there is also a sub-population of dimeric (RC) PK-A enzymes that are not tethered by AKAPs | Caenorhabditis elegans |
Synonyms | Comment | Organism |
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PK-A | - |
Caenorhabditis elegans |
protein kinase A | - |
Caenorhabditis elegans |