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Literature summary for 2.7.11.11 extracted from

  • Cognard, E.; Dargaville, C.G.; Hay, D.L.; Shepherd, P.R.
    Identification of a pathway by which glucose regulates beta-catenin signalling via the cAMP/protein kinase A pathway in beta-cell models (2013), Biochem. J., 449, 803-811.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
D-glucose increases phosphorylation of beta-catenin on Ser552 in INS-1E beta-cells Rattus norvegicus
N6,2'-O-dibutyryl-cAMP increases phosphorylation of beta-catenin on Ser552 in INS-1E beta-cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-catenin Rattus norvegicus
-
 ADP + phosphorylated beta-cateniin
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1E cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin
-
 Rattus norvegicus ADP + phosphorylated beta-cateniin
-
 ?
ATP + beta-catenin phosphorylation on Ser552 and Ser675 Rattus norvegicus ADP + phosphorylated beta-cateniin
-
 ?

Synonyms

Synonyms Comment Organism
cAMP/protein kinase A
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function PKA catalyzed phosphorylation of beta-catenin at Ser552 and Ser675 results in stabilization of the protein and activation of its transcriptional activity. beta-Catenin is required for the glucose-dependent increase in cyclin D1 expression in INS-1E beta-cells Rattus norvegicus