Literature summary for 2.7.11.11 extracted from

Abu-Abed, M.; Das, R.; Wang, L.; Melacini, G.
Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha (2007), Proteins, 69, 112-124.

Search for more literature for 2.7.11.11

Activating Compound

Activating Compound	Comment	Organism	Structure
cAMP	-	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
D170A	site-directed mutagenesis of the regulatory subunit RIalpha, the mutation selectively reduces the negative cooperativity between the cAMP- and C-recognition sites, i.e. the KD for the regulatory-catalytic subunit complex in the presence of cAMP is reduced by more than 12fold, without significantly compromising the high affinity of the regulatory subunit for both binding partners, conformational shifts upon mutation, and physiological implications of the dual functionality of the D170A mutant, overview	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Bos taurus	5737	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the regulatory subunit of PKA inhibits its kinase activity by shielding the catalytic subunit from physiological substrates, Asp170 not only plays a pivotal role in controlling the local conformation of the phosphate binding cassette, where cAMP docks, but also significantly affects the long-range cAMP-dependent interaction network that extends from the phosphate binding cassette to the three major sites of C-recognition	Bos taurus	?	-	?

Subunits

Subunits	Comment	Organism
More	the regulatory subunit of PKA inhibits its kinase activity by shielding the catalytic subunit from physiological substrates, interdependence between the Asp170 relay site and the regulatory-catalytic subunit interaction interface	Bos taurus

Synonyms

Synonyms	Comment	Organism
PKA	-	Bos taurus
protein kinase A	-	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Bos taurus

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Release 2023.1 (January 2023)