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Literature summary for 2.7.11.11 extracted from

  • Borthwick, L.A.; McGaw, J.; Conner, G.; Taylor, C.J.; Gerke, V.; Mehta, A.; Robson, L.; Muimo, R.
    The formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function (2007), Mol. Biol. Cell, 18, 3388-3397.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
Calcineurin i.e. CaN, is important for the cAMP/PKA-dependent anx 2–S100A10 complex formation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
STVHEILCKLSLEG an acetylated peptide Ac1-14, but not the nonacetylated equivalent N1-14, inhibits PKA-dependent outwardly rectifying Cl- channels, ORCC, and CFTRmediated currents, the peptide sequence is equivalent to the S100A10 binding site on anx 2, it disrupts the anx S100A10/CTFR interaction Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane cAMP/PKA-dependent anx 2–S100A10 complex Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cystic fibrosis results from mutations in the cystic fibrosis conductance regulator protein, CFTR, a cAMP/protein kinase A, PKA, and ATP-regulated Cl- channel, the formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein, CFTR, regulates CFTR channel function, overview, PKA regulates anx 2 and S100A10 cellular distribution in HNE cells, modulation of PKA activity alters localization and distribution of anx 2–S100A10 in HNE cells, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium nasal Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cystic fibrosis results from mutations in the cystic fibrosis conductance regulator protein, CFTR, a cAMP/protein kinase A, PKA, and ATP-regulated Cl- channel, the formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein, CFTR, regulates CFTR channel function, overview, PKA regulates anx 2 and S100A10 cellular distribution in HNE cells, modulation of PKA activity alters localization and distribution of anx 2–S100A10 in HNE cells, overview Homo sapiens ?
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Synonyms

Synonyms Comment Organism
cAMP/protein kinase A
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 Homo sapiens
PKA
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
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 Homo sapiens