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Literature summary for 2.7.11.11 extracted from
- Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue (2007), J. Proteome Res., 6, 1705-1717.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | - |
Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression of paralemmin 2-AKAP2 fusion protein in ventricular tissue | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes | Mus musculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in cyclic nucleotide signaling, overview, individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes, providing a multifaceted platform for the kinase | ? | - |
? | |
| additional information | Mus musculus FVB/N | the enzyme is involved in cyclic nucleotide signaling, overview, individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes, providing a multifaceted platform for the kinase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
FVB/N mice | - |
| Mus musculus FVB/N | - |
FVB/N mice | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | analysis of in vivo phosphorylation sites on PKA-R reveals the presence of several differentially phosphorylated PKA-R isoforms, using semiquantitative mass spectrometry, overview | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Mus musculus | - |
| heart ventricle | isozyme distribution | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in cyclic nucleotide signaling, overview, individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes, providing a multifaceted platform for the kinase | Mus musculus | ? | - |
? | |
| additional information | the enzyme is involved in cyclic nucleotide signaling, overview, individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes, providing a multifaceted platform for the kinase | Mus musculus FVB/N | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | identification of protein kinase A regulatory isoforms and of 11 different A-kinase anchoring proteins, AKAPs, in ventricular tissue, overview | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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