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Literature summary for 2.7.11.11 extracted from

  • Kim, J.A.; Park, J.Y.; Kang, H.W.; Huh, S.U.; Jeong, S.W.; Lee, J.H.
    Augmentation of Cav3.2 T-type calcium channel activity by cAMP-dependent protein kinase A (2006), J. Pharmacol. Exp. Ther., 318, 230-237.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cAMP
-
 Xenopus laevis
forskolin
-
 Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information reconstitution of the PKA cascade in Xenopus laevis oocytes, overview Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
H89 i.e. N-[2-(4-bromocinnamylamino) ethyl]-5-isoquinoline Xenopus laevis
protein kinase A inhibitor peptide PKI
-
 Xenopus laevis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of enzyme activity and activation Xenopus laevis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
 mature female frogs
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5HT7 receptor recombinant rat 5HT7 receptor reconstituted in frog oocytes, overview Xenopus laevis ADP + phosphorylated 5HT7 receptor
-
 ?
ATP + Cav3.2 T-type Ca2+ channel recombinant human Ca2+ channel reconstituted in frog oocytes, overview Xenopus laevis ADP + phosphorylated Cav3.2 T-type Ca2+ channel
-
 ?
ATP + Nav1.4 T-type Na+ channel recombinant rat Na+ channel reconstituted in frog oocytes, overview Xenopus laevis ADP + phosphorylated Nav1.4 T-type Na+ channel
-
 ?
additional information the localization of the structural region of the reconstituted channel protein substrates contribute to PKA-mediated stimulation Xenopus laevis ?
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase A
-
 Xenopus laevis
PKA
-
 Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Xenopus laevis