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Literature summary for 2.7.11.11 extracted from

  • Hall, D.D.; Davare, M.A.; Shi, M.; Allen, M.L.; Weisenhaus, M.; McKnight, G.S.; Hell, J.W.
    Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons (2007), Biochemistry, 46, 1635-1646.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cAMP
-
Rattus norvegicus
additional information beta-adrenergic stimulation of Ser1928 phosphorylation, L-type calcium channel Cav1.2 constitutively associates with the beta2-AR and PKA to efficiently respond to beta-adrenergic activation Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information deletion of the AKAP150 gene abrogates stimulation of alpha11.2 phosphorylation on Ser1928 in vivo, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + A-kinase anchor protein Rattus norvegicus phosphorylation at Ser1928 ADP + phosphorylated A-kinase anchor protein
-
?
ATP + Cav1.2 Rattus norvegicus in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain ADP + phosphorylated Cav1.2
-
?
additional information Rattus norvegicus enzyme regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Harlan Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + A-kinase anchor protein phosphorylation at Ser1928 Rattus norvegicus ADP + phosphorylated A-kinase anchor protein
-
?
ATP + A-kinase anchor protein i.e. AKAP, phosphorylation at Ser1928, the rat enzyme is active with different AKAP substrate variants from different sources, overview Rattus norvegicus ADP + phosphorylated A-kinase anchor protein
-
?
ATP + Cav1.2 in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain Rattus norvegicus ADP + phosphorylated Cav1.2
-
?
ATP + Cav1.2 an L-type calcium channel Cav1.2 Rattus norvegicus ADP + phosphorylated Cav1.2
-
?
additional information enzyme regulation, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PKA
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus