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Literature summary for 2.7.11.11 extracted from
- Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability (2005), J. Biol. Chem., 280, 25170-25177.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | dependent on | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + lactate dehydrogenase subunit A mRNA | Rattus norvegicus | the enzyme stabilizes lactate dehydrogenase LDH-A mRNA and increases intracellular LDH-A mRNA levels by phosphorylation of a cAMP-stabilizing region CSR on the 3'-untranslated region of the LDH-A mRNA, regulation, mechanism | ADP + 3'-UTR phosphorylated lactate dehydrogenase subunit A mRNA | - |
? | |
| additional information | Rattus norvegicus | PKA regulatory and catalytic subunits are bound in the CSR complex including the protein kinase A anchoring protein AKAP 95 and several CSR-binding proteins, the complex acts in stabilizing the LDH-A mRNA, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| regulatory subunit RII from C6 cells by affinity chromatography on an 8-(6-aminohexyl)-amino-cAMP-resin | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C6 glioma cell | glioma cell line | Rattus norvegicus | - |
| glioma cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + lactate dehydrogenase subunit A mRNA | - |
Rattus norvegicus | ADP + 3'-UTR phosphorylated lactate dehydrogenase subunit A mRNA | - |
? | |
| ATP + lactate dehydrogenase subunit A mRNA | the enzyme stabilizes lactate dehydrogenase LDH-A mRNA and increases intracellular LDH-A mRNA levels by phosphorylation of a cAMP-stabilizing region CSR on the 3'-untranslated region of the LDH-A mRNA, regulation, mechanism | Rattus norvegicus | ADP + 3'-UTR phosphorylated lactate dehydrogenase subunit A mRNA | - |
? | |
| additional information | PKA regulatory and catalytic subunits are bound in the CSR complex including the protein kinase A anchoring protein AKAP 95 and several CSR-binding proteins, the complex acts in stabilizing the LDH-A mRNA, overview | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 2 regulatory subunits in a dimer bound to 2 catalytic subunits, the latter are released during activation by cAMP | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Rattus norvegicus |
| protein kinase A | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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