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Literature summary for 2.7.11.11 extracted from

  • Viste, K.; Kopperud, R.K.; Christensen, A.E.; Doskeland, S.O.
    Substrate enhances the sensitivity of type I protein kinase a to cAMP (2005), J. Biol. Chem., 280, 13279-13284.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview Homo sapiens
cAMP dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
additional information the regulatory subunits competitively inhibit the PKA kinase activity Bos taurus
additional information the regulatory subunits competitively inhibit the PKA kinase activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine catalytic subunit C and human regulatory subunits RI and RII
-
Homo sapiens
-
 bovine catalytic subunit C and human regulatory subunits RI and RII
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Kemptide activity of catalytic PKA subunit Homo sapiens ADP + phosphorylated Kemptide
-
 ?
ATP + Kemptide activity of catalytic PKA subunit Bos taurus ADP + phosphorylated Kemptide
-
 ?
ATP + tyrosine hydroxylase activity of catalytic PKA subunit Homo sapiens ADP + phosphorylated tyrosine hydroxylase
-
 ?
ATP + tyrosine hydroxylase activity of catalytic PKA subunit Bos taurus ADP + phosphorylated tyrosine hydroxylase
-
 ?

Synonyms

Synonyms Comment Organism
type I protein kinase A
-
 Homo sapiens
type I protein kinase A
-
 Bos taurus
type II protein kinase A
-
 Homo sapiens
type II protein kinase A
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Bos taurus