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Literature summary for 2.7.11.11 extracted from

  • Zhou, R.; Cao, X.; Watson, C.; Miao, Y.; Guo, Z.; Forte, J.G.; Yao, X.
    Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activation (2003), J. Biol. Chem., 278, 35651-35659.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information substrate ezrin is localized at the cytoskeleton of the apical plasma membrane Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ezrin Oryctolagus cuniculus recombinant GST-tagged wild-type ezrin transiently expressed in primary gastric parietal cells from stomach, recombinant mutant S66A and S66D ezrin proteins are no substrates, phosphorylation of ezrin leads to activation of parietal cells required for dilation of apical vacuolar membrane and histamine-stimulated acid secretion in gastric mucosa, overview ADP + phosphoezrin
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric gland
-
 Oryctolagus cuniculus
-
mucosa gastric Oryctolagus cuniculus
-
stomach
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ezrin recombinant GST-tagged wild-type ezrin transiently expressed in primary gastric parietal cells from stomach, recombinant mutant S66A and S66D ezrin proteins are no substrates, phosphorylation of ezrin leads to activation of parietal cells required for dilation of apical vacuolar membrane and histamine-stimulated acid secretion in gastric mucosa, overview Oryctolagus cuniculus ADP + phosphoezrin
-
 ?
ATP + ezrin phosphorylation at Ser66, catalytic subunit of PKA Oryctolagus cuniculus ADP + phosphoezrin
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Oryctolagus cuniculus
protein kinase A
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus