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Literature summary for 2.7.11.11 extracted from

  • Orstavik, S.; Funderud, A.; Hafte, T.T.; Eikvar, S.; Jahnsen, T.; Skalhegg, B.S.
    Identification and characterization of novel PKA holoenzymes in human T lymphocytes (2005), FEBS J., 272, 1559-1567.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
8-CPT-cAMP induces release of the active catalytic subunits from the PKA holoenzyme Homo sapiens
cAMP induces release of the active catalytic subunits from the PKA holoenzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol subunit RIalpha localizes at the membrane/cytosolic area, subunit RIIalpha is concentrated around the Golgi-centrosomal area, subunits Calpha1 and Cbeta2 in colocalized with RIalpha and RIIalpha Homo sapiens 5829
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 2 isozymes PKAI and PKAII
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Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
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NTERA-2 cell
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 Homo sapiens
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T-cell
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 Homo sapiens
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T-lymphocyte
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 Homo sapiens
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Subunits

Subunits Comment Organism
monomer 1 x 40000, activated catalytic subunit Calpha1, 1 x 47000, activated catalytic subunit Cbeta2 Homo sapiens
More enzyme consists of 2 catalytic subunits bound to a regulatory subunit dimer of subunits RIalpha and RIIalpha, the catalytic subunits are released upon activation by cAMP, 2 isoforms of catalytic subunit C exist, subunits Calpha1 and Cbeta2, which can colocalize in 1 holoenzyme complex Homo sapiens

Synonyms

Synonyms Comment Organism
cyclic AMP-dependent protein kinase
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 Homo sapiens
PKA
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 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
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 assay at Homo sapiens