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Literature summary for 2.7.11.11 extracted from

  • Vigil, D.; Blumenthal, D.K.; Brown, S.; Taylor, S.S.; Trewhella, J.
    Differential effects of substrate on type I and type II PKA holoenzyme dissociation (2004), Biochemistry, 43, 5629-5636.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on, activates the enzyme by partly dissociating the regulatory and the catalytic subunits, determination and analysis of the mechanism, the substrate plays a differential role in activation of type I versus type II holoenzyme Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
distinct expression of catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta in Escherichia coli strain 222 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate activation mechanism Bos taurus
a

Renatured (Commentary)

Renatured (Comment) Organism
recombinant catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta from Escherichia coli strain 222 by cAMP-affinity chromatography, gel filtration, and dialysis Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Kemptide catalytic subunit C Bos taurus ADP + Kemptide phosphate
-
 ?
additional information substrates have differential effects on type I and type II PKA holoenzyme dissociation, the isolated catalytic subunit is catalytically active Bos taurus ?
-
 ?

Subunits

Subunits Comment Organism
More substrates have differential effects on type I and type II PKA holoenzyme dissociation, X-ray scattering measurements, overview Bos taurus

Synonyms

Synonyms Comment Organism
protein kinase A
-
 Bos taurus
type I PKA
-
 Bos taurus
type II PKA
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus