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Literature summary for 2.7.11.11 extracted from
- Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle (2003), Am. J. Physiol. Gastronintest. Liver Physiol., 284, G221-230.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | - |
Oryctolagus cuniculus |  |
| cBIMPS | - |
Oryctolagus cuniculus | |
| forskolin | activates at concentration above 0.001 mM | Oryctolagus cuniculus | |
| isoproterenol | at concentration below 0.001 mM | Oryctolagus cuniculus | |
| Vasoactive intestinal peptide | i.e. VIP | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| myristoylated PKI14-22 amide | selective peptide inhibitor of P KA | Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Oryctolagus cuniculus | inositol 1,4,5-trisphosphate receptor-I is no substrate of PKA in vivo | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| smooth muscle cell | gastric, primary | Oryctolagus cuniculus | - |
| stomach | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + inositol 1,4,5-trisphosphate receptor-I | isolated catalytic subunit of PKA, selective phosphorylation at Ser1589 and Ser1755 | Oryctolagus cuniculus | ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I | - |
? | |
| additional information | inositol 1,4,5-trisphosphate receptor-I is no substrate of PKA in vivo | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 31 | - |
in vivo phosphorylation assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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