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Literature summary for 2.7.11.1 extracted from

  • Koyano, T.; Barnouin, K.; Snijders, A.; Kume, K.; Hirata, D.; Toda, T.
    Casein kinase 1gamma acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast (2015), Genes Cells, 20, 1046-1058 .
No PubMed abstract available
Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GFP-tagged enzyme in Cki3DELTA cells Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Schizosaccharomyces pombe 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Tea1 Schizosaccharomyces pombe
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 ADP + phospho-Tea1
-
 ?
ATP + Tea1 Schizosaccharomyces pombe ATCC 24843
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 ADP + phospho-Tea1
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O74135
-
-
Schizosaccharomyces pombe ATCC 24843 O74135
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Tea1
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 Schizosaccharomyces pombe ADP + phospho-Tea1
-
 ?
ATP + Tea1 polarity factor Tea1, Cki3-mediated phosphorylation of protein Tea1 at five serine residues, including S502, S503, S553, S556, and S476, overview Schizosaccharomyces pombe ADP + phospho-Tea1
-
 ?
ATP + Tea1
-
 Schizosaccharomyces pombe ATCC 24843 ADP + phospho-Tea1
-
 ?
ATP + Tea1 polarity factor Tea1, Cki3-mediated phosphorylation of protein Tea1 at five serine residues, including S502, S503, S553, S556, and S476, overview Schizosaccharomyces pombe ATCC 24843 ADP + phospho-Tea1
-
 ?

Synonyms

Synonyms Comment Organism
casein kinase 1gamma
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 Schizosaccharomyces pombe
CK1gamma
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 Schizosaccharomyces pombe
Cki3
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 Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
evolution conserved casein kinase 1 (CK1) comprises a large protein family, consisting of four isoforms (alpha, gamma, delta and epsilon) that serve a wide range of cellular functions as key signaling molecules Schizosaccharomyces pombe
malfunction cki3DELTA mutant cells become hypersensitive to Calcofluor White, indicating that NETO execution at a proper cell cycle stage is important for the maintenance of cell integrity, although the involvement of Cki3 in cell integrity independent of NETO regulation is also possible. Cells containing a kinase-dead version of Cki3 (Cki3KD) or membrane localization-defective Cki3SS mutant also displays a similar faster mobility of Tea1 Schizosaccharomyces pombe
physiological function Schizosaccharomyces pombe undergoes growth polarity transition from monopolar to bipolar during G2 phase, designated NETO (New End Take Off). NETO onset involves two prerequisites, the completion of DNA replication and attainment of a certain cell size. Casein kinase 1gamma, Cki3, acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast. Cki3 kinase activity is required for the delay in NETO onset downstream of Cds1/CHK2 and calcineurin when S-phase is blocked. Cki3 is a critical determinant of NETO onset. Phosphomimetic Tea1 mutants show compromised binding to Tea4 and NETO defects, indicating that these serine residues are critical for protein-protein interaction and NETO onset. Cki3 ensured the proper timing of NETO during the cell cycle, which is necessary for a temporal coupling between polarized growth and cell wall organization. Tea1is negatively regulated by Cki3-mediated phosphorylation, mechanism, overview. Induced entrapment of Tea1 by enzyme Cki3 results in constitutive hyperphosphorylation of Tea1 with monopolar growth. Tea1 forms a stable complex with Tea4, but dissociates from hyperphosphorylated Tea1. Tea4 becomes delocalized from the cell tips in the absence of Tea1 Schizosaccharomyces pombe