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Literature summary for 2.7.11.1 extracted from

  • Dong, Q.; Giorgianni, F.; Beranova-Giorgianni, S.; Deng, X.; OMeally, R.; Bridges, D.; Park, E.; Cole, R.; Elam, M.; Raghow, R.
    Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation (2016), Biosci. Rep., 36, e00284 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + SREBP-1c Rattus norvegicus sterol response element binding protein-1c, phosphorylation of Ser73 ADP + phospho-SREBP-1c
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18266
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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 Rattus norvegicus
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liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + SREBP-1c sterol response element binding protein-1c, phosphorylation of Ser73 Rattus norvegicus ADP + phospho-SREBP-1c
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ATP + SREBP-1c sterol response element binding protein-1c phosphorylation of Ser73 Rattus norvegicus ADP + phospho-SREBP-1c
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additional information recombinant expression of His6- or HA-tagged full-length substrate SREBP-1c and its loss-of-function mutant S73A and gain-of-function mutant S73D in McA-RH7777 cells, overview. The sequence surrounding serine 73 of rat SREBP-1c resembles a canonical cdc4 phosphodegron (CPD) that is a recognized substrate of the SCFFbw7 ubiquitin ligase Rattus norvegicus ?
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Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
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 Rattus norvegicus
GSK-3
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 Rattus norvegicus
GSK-3beta
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
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 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition or knockdown of GSK-3 differentially regulates the turnover of wild-type and S73A SREBP-1c proteins Rattus norvegicus
physiological function glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for ubiquitination and proteasomal degradation. Also phospho-mimetic mutation of serine 73 targets SREBP-1c for proteasomal degradation. Constitutive phosphorylation at serine 73 (as is the case for the S73D mutant of SREBP-1c) results in reduced affinity of the pSREBP–SCAP complex in the endoplasmic reticulum. The S73D pSREBP-1c mutant becomes free and is targeted for rapid proteasomal degradation Rattus norvegicus