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Literature summary for 2.7.11.1 extracted from
- Quantitative analysis of dynamic protein interactions during transcription reveals a role for casein kinase II in Polymerase-associated Factor (PAF) complex phosphorylation and regulation of histone H2B monoubiquitylation (2016), J. Biol. Chem., 291, 13410-13420.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + PAF-C protein | Saccharomyces cerevisiae | - |
ADP + phosphorylated PAF-C protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + PAF-C protein | - |
Saccharomyces cerevisiae | ADP + phosphorylated PAF-C protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase II | - |
Saccharomyces cerevisiae |
| CKII | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | decreased enzyme function in vivo results in decreased levels of histone H2B lysine 123 monoubiquitylation | Saccharomyces cerevisiae |
| metabolism | the enzyme plays a coordinated role in the regulation of RNA polymerase II transcription through chromatin via phosphorylation of the polymerase-associated factor complex PAF-C | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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