Activating Compound | Comment | Organism | Structure |
---|---|---|---|
beta-adrenergic agonist isopreterenol | - |
Rattus norvegicus | |
endothelin-1 | - |
Rattus norvegicus | |
Insulin | - |
Rattus norvegicus | |
insulin-like growth factor 1 | - |
Rattus norvegicus | |
phenylephrine | - |
Rattus norvegicus | |
phorbol 12-myristate 13-acetate | - |
Rattus norvegicus | |
platelet-derived growth factor | - |
Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli as a GST-fusion protein | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Akt signaling is impaired by Pak1 gene silencing or targeted deletion | Rattus norvegicus |
additional information | Pak1 overexpression in neonatal rat ventricular cardiomyocytes is able to reduce cardiotoxicity of doxorubicin (DOX), an anticancer drug that can kill neonatal rat ventricular cardiomyocytes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | PI3K inhibitor | Rattus norvegicus | |
wortmanin | PI3K inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P07564 | - |
- |
Rattus norvegicus | P35465 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | - |
Rattus norvegicus | - |
heart | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
Cardiac Pak1 activity is markedly increased by transverse aortic constriction in both C57BL/6 and FVBN mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt (MBP) | purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes | Rattus norvegicus | ADP + phosphorylated-Akt | - |
? | |
ATP + myelin basic protein (MBP) | - |
Rattus norvegicus | ADP + phosphorylated-myelin basic protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P21-activated kinase-1 | - |
Rattus norvegicus |
P21-activated kinase-1 | - |
Mus musculus |
Pak1 | - |
Rattus norvegicus |
Pak1 | - |
Mus musculus |
PDK2 | - |
Rattus norvegicus |
phosphoinositide-dependent protein kinase-2 | - |
Rattus norvegicus |
phosphoinositide-dependent protein kinase-2 | - |
Mus musculus |