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Literature summary for 2.7.11.1 extracted from

  • Mao, K.; Kobayashi, S.; Jaffer, Z.M.; Huang, Y.; Volden, P.; Chernoff, J.; Liang, Q.
    Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes (2008), J. Mol. Cell. Cardiol., 44, 429-434.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
beta-adrenergic agonist isopreterenol
-
Rattus norvegicus
endothelin-1
-
Rattus norvegicus
Insulin
-
Rattus norvegicus
insulin-like growth factor 1
-
Rattus norvegicus
phenylephrine
-
Rattus norvegicus
phorbol 12-myristate 13-acetate
-
Rattus norvegicus
platelet-derived growth factor
-
Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli as a GST-fusion protein Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information Akt signaling is impaired by Pak1 gene silencing or targeted deletion Rattus norvegicus
additional information Pak1 overexpression in neonatal rat ventricular cardiomyocytes is able to reduce cardiotoxicity of doxorubicin (DOX), an anticancer drug that can kill neonatal rat ventricular cardiomyocytes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LY294002 PI3K inhibitor Rattus norvegicus
wortmanin PI3K inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus P07564
-
-
Rattus norvegicus P35465
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
Rattus norvegicus
-
heart
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
Cardiac Pak1 activity is markedly increased by transverse aortic constriction in both C57BL/6 and FVBN mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt (MBP) purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes Rattus norvegicus ADP + phosphorylated-Akt
-
?
ATP + myelin basic protein (MBP)
-
Rattus norvegicus ADP + phosphorylated-myelin basic protein
-
?

Synonyms

Synonyms Comment Organism
P21-activated kinase-1
-
Rattus norvegicus
P21-activated kinase-1
-
Mus musculus
Pak1
-
Rattus norvegicus
Pak1
-
Mus musculus
PDK2
-
Rattus norvegicus
phosphoinositide-dependent protein kinase-2
-
Rattus norvegicus
phosphoinositide-dependent protein kinase-2
-
Mus musculus