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Literature summary for 2.7.11.1 extracted from

  • Cozzone, D.; Froejdoe, S.; Disse, E.; Debard, C.; Laville, M.; Pirola, L.; Vidal, H.
    Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients (2008), Diabetologia, 51, 512-521.
    View publication on PubMed
Search for more literature for 2.7.11.1

Activating Compound

Activating Compound Comment Organism Structure
Insulin in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt1-Thr308 phosphorylation Homo sapiens
Insulin in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation Homo sapiens
Insulin in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt3-Ser473 phosphorylation Homo sapiens
Insulin in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display defective insulin action and a drastic reduction of insulin stimulated activity of all Akt isoforms Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31749
-
-
Homo sapiens P31751
-
-
Homo sapiens Q9Y243
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens
phosphoprotein Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation and a higher level of the Akt2-Ser473-specific protein phosphatase PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) in muscle from diabetic patients Homo sapiens
phosphoprotein Muscle cells from diabetic patients display an impaired Akt3-Ser473 phosphorylation and a higher level of the Akt3-Ser473-specific protein phosphatase PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) in muscle from diabetic patients Homo sapiens
phosphoprotein Muscle cells from diabetic patients display an impaired Akt3-Thr308 phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Homo sapiens
-
muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein
-
 Homo sapiens ADP + phosphorylated- glycogen synthase kinase-3 fusion protein
-
 ?

Synonyms

Synonyms Comment Organism
AKT
-
 Homo sapiens
AKT1
-
 Homo sapiens
AKT2
-
 Homo sapiens
Akt3
-
 Homo sapiens
PKB
-
 Homo sapiens
protein kinase B
-
 Homo sapiens
serine/threonine kinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens