Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.1 extracted from

  • Pagano, M.A.; Cesaro, L.; Meggio, F.; Pinna, L.A.
    Protein kinase CK2: a newcomer in the druggable kinome (2006), Biochem. Soc. Trans., 34, 1303-1306.
    View publication on PubMed
Search for more literature for 2.7.11.1

Application

Application Comment Organism
drug development CK2 is a target for drug development and design of selective inhibitors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid i.e. IQA Homo sapiens
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole i.e DMAT Homo sapiens
3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one i.e. DBC Homo sapiens
4,5,6,7-tetrabromo-1H-benzotriazole i.e. TBB Homo sapiens
8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one i.e. NBC Homo sapiens
ellagic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview Homo sapiens ?
-
 ?
additional information CK2 contains a consensus sequence in which a carboxylic acid side chain at position n+3 relative to the target serine/threonine residue plays a crucial role for activity, CK2 shows a broad substrate specificity of diverse proteins Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CK2
-
 Homo sapiens
protein kinase CK2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
-
 Homo sapiens ellagic acid
0.0001
-
-
 Homo sapiens 3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one
0.00014
-
-
 Homo sapiens 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
0.0003
-
-
 Homo sapiens 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
0.00039
-
-
 Homo sapiens (5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
0.0005
-
-
 Homo sapiens 4,5,6,7-tetrabromo-1H-benzotriazole