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Literature summary for 2.7.11.1 extracted from
- Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates (2003), J. Med. Virol., 70 Suppl 1, S95-102.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| putrescine | aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity | Human alphaherpesvirus 3 |  |
| spermidine | aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity | Human alphaherpesvirus 3 | |
| spermine | aliphatic, positively charged polyamine, required for in vitro activity of ORF47, polyamine depletion leads to 80% reduced activity | Human alphaherpesvirus 3 | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | strongly inhibits casein kinase II | Homo sapiens | |
| additional information | ORF47 kinase is resistant to heparin, host cell pretreatment prior to virus infection with D,L-alpha-difluoromethylornithine reduces intracellular polyamine concentration and thus inhibits the viral enzyme ORF47 | Human alphaherpesvirus 3 |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Human alphaherpesvirus 3 | - |
VZV-32, propagated in MeWo human melanoma cells | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| melanoma cell | - |
Homo sapiens | - |
| MeWo cell | melanoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + casein | - |
Human alphaherpesvirus 3 | ADP + phosphorylated casein | - |
? | |
| ATP + IgG2A heavy chain | substrate protein from mouse | Human alphaherpesvirus 3 | ADP + phosphorylated IgG2A heavy chain | - |
? | |
| ATP + maltose-binding protein | - |
Human alphaherpesvirus 3 | ADP + phosphorylated maltose-binding protein | - |
? | |
| ATP + ORF62 protein | protein substrate from Varicella-Zoster virus, no activity with a truncated ORF62 mutant | Human alphaherpesvirus 3 | ADP + ORF62 phosphoprotein | - |
? | |
| ATP + ORF63 protein | protein substrate from Varicella-Zoster virus | Human alphaherpesvirus 3 | ADP + ORF63 phosphoprotein | - |
? | |
| ATP + Varicella-Zoster viral gB protein | phosphorylation at S34 in the sequence QSEDIT | Homo sapiens | ADP + phosphorylated Varicella-Zoster viral gB protein | - |
? | |
| additional information | CKII phosphorylates serine or threonine residues with an acidic amino acid in the +2 or +3 position | Homo sapiens | ? | - |
? | |
| additional information | the minimal consensus sequence of ORF47 is S/T-X-D/E-D/E, no activity of ORF47 with glutathione S-transferase, or Varicella-Zoster viral gB protein | Human alphaherpesvirus 3 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase II | - |
Homo sapiens |
| CKII | - |
Homo sapiens |
| ORF47 protein | - |
Human alphaherpesvirus 3 |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Human alphaherpesvirus 3 | |
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