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Literature summary for 2.7.11.1 extracted from
- FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation (2005), J. Biol. Chem., 280, 270-276.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| FRAT-2 | i.e. frequently rearranged in advanced T-cell lymphoma protein 2, activates phosphorylation of primed sites of tau protein about 8fold, no effect on unprimed site phosphorylation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient co-expression of human tau long isoform, HA-tagged GSK3beta, and GST-tagged GFP-fusion FRAT-2 protein in HEK-293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S9A | site-directed mutagenesis, mutant cannot be inhibited by phosphorylation at position 9 and is thus constitutively active | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | Homo sapiens | tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins | ADP + O-phospho -[tau-protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phospho-glycogen synthase peptide | - |
Homo sapiens | ADP + ? | - |
? | |
| ATP + [FRAT-2 protein] | i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta | Homo sapiens | ADP + phosphorylated [FRAT-2 protein] | - |
? | |
| ATP + [tau-protein] | tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins | Homo sapiens | ADP + O-phospho -[tau-protein] | - |
? | |
| ATP + [tau-protein] | phosphorylation of primed and unprimed sites by GSK3beta, wild-type and recombinant tau, recombinant GSK3beta S9A | Homo sapiens | ADP + O-phospho -[tau-protein] | - |
? | |
| additional information | GSK3beta catalyzes tau phosphorylation, EC 2.7.11.1, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen synthase kinase 3 beta | - |
Homo sapiens |
| GSK3beta | - |
Homo sapiens |
| More | see also EC 2.7.11.26 | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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