Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.1 extracted from

  • Wang, Z.; Yang, C.L.; Ellison, D.H.
    Comparison of WNK4 and WNK1 kinase and inhibiting activities (2004), Biochem. Biophys. Res. Commun., 317, 939-944.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information WKN4 needs to be activated for activity Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-fusion WNK4 and WNK1 kinases in Escherichia coli strain BL21(DE3), expression of WNK4 and WNK1 kinases, and of the autoinhibitory domain of WNK4, residues 444-518 and 444-563, as well as the N-terminal domain 1-443 in HEK-293T cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information WKN4 possesses an autoinhibitory domain, residues 444-518, the isolated autoinhibitory domainin 1-443 inhibits WKN1 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation of WKN1 and WKN4 Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-fusion WNK4 and WNK1 kinases from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone
-
Rattus norvegicus ADP + phosphorylated histone
-
?
additional information WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane Rattus norvegicus ?
-
?
additional information WKN1 and WKN4 perform autophosphorylation Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
WNK1 kinase
-
Rattus norvegicus
WNK4 kinase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus