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Literature summary for 2.7.11.1 extracted from

  • Bernard, P.; Hardwick, K.; Javerzat, J.P.
    Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis (1998), J. Cell. Biol., 143, 1775-1787.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Localization

Localization Comment Organism GeneOntology No. Textmining
centromere mitotic, activation of the checkpoint results in the recruitment of Bub1 to centromeres, Bub1 is recruited to kinetochores during the early stages of mitosis. A pool of Bub1 remains centromere-associated at metaphase and even until telophase Schizosaccharomyces pombe
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kinetochore activation of the checkpoint results in the recruitment of Bub1 to centromeres, Bub1 is recruited to kinetochores during the early stages of mitosis. A pool of Bub1 remains centromere-associated at metaphase and even until telophase Schizosaccharomyces pombe 776
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Schizosaccharomyces pombe the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis ADP + a phosphoprotein
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Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O94751
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis Schizosaccharomyces pombe ADP + a phosphoprotein
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Synonyms

Synonyms Comment Organism
checkpoint serine/threonine-protein kinase bub1
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 Schizosaccharomyces pombe