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Literature summary for 2.7.11.1 extracted from

  • Ouyang, B.; Lan, Z.; Meadows, J.; Pan, H.; Fukasawa, K.; Li, W.; Dai, W.
    Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation (1998), Cell Growth Differ., 9, 877-885.
    View publication on PubMed
Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment) Organism
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 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore
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 Homo sapiens 776
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additional information hBub1 protein colocalizes with a centromere-kinetochore antigen CREST in interphase, mitotic prophase, and nocodazole-treated cells Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression ADP + a phosphoprotein
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43683
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-

Source Tissue

Source Tissue Comment Organism Textmining
Dami cell leukemia cell line, cells undergo terminal differentiation after treatment with phorbol ester, hBub1 expression in this cell line is down-regulated rapidly Homo sapiens
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additional information hBub1 mRNA level is abundantly expressed in tissues or cells with a high mitotic index. The hBub1 protein level is low in G1 and remains relatively constant in S, G2, and M phases Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression Homo sapiens ADP + a phosphoprotein
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 ?

Synonyms

Synonyms Comment Organism
mitotic checkpoint serine/threonine-protein kinase BUB1
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 Homo sapiens